| abstract |
The invention discloses a method for synthesizing the key intermediate (R)-3-aminobutanol of dolutegravir, the synthesis route of which is: The present invention designs a synthesis route of R-3-aminobutanol suitable for large-scale industrial production, which not only effectively improves the optical purity of the product, avoids the use of hazardous raw materials, but also has a high yield of the product, which is suitable for industrial promotion and application. |