http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106730052-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L33-0023 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L33-128 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L33-0076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L33-068 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-12 |
| filingDate | 2017-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106730052-B |
| titleOfInvention | Silk fibroin anticoagulant material and preparation method thereof |
| abstract | The invention provides a preparation method of a silk fibroin anticoagulant material, which comprises the following steps: s1) mixing the silk fibroin solution, polyethylene glycol diamine and a cross-linking agent, reacting, dialyzing and drying to obtain a polyethylene glycol diamine cationized silk fibroin material; s2) soaking the silk fibroin material cationized by polyethylene glycol diamine in a hirudin solution to obtain the silk fibroin anticoagulation material. Compared with the prior art, the preparation method provided by the invention protects the functional group in the thrombin binding region from being affected by reaction to the thrombin binding domain, and enables hirudin to be bound to the polyethylene glycol diamine cationized silk fibroin by strong binding force ionic bonds to stably exert the anticoagulation effect, so that the obtained silk fibroin anticoagulation material has the function of obviously inhibiting the thrombin activity, and can be particularly applied to preventing neointimal hyperplasia of artificial blood vessels and formation of postoperative thrombus. |
| priorityDate | 2017-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.