http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106729769-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_048f16c527f4c5abde2048c4436c331b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1029 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0056 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate | 2017-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60dd15eee98faa12ec0f158f1bcb9d34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60ecde8830861f5c8a7688d01c4940af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf400c9c8453b3fbea563b91faedef79 |
| publicationDate | 2017-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106729769-A |
| titleOfInvention | TEM1 specific fluorescent probe and its application |
| abstract | The present invention provides a TEM1-specific fluorescent probe, which includes an anti-TEM1 single-chain antibody, a linker MAL-PEG-NH 2 and a fluorescent dye ICG-NHS, wherein the fluorescent dye ICG-NHS is linked to The C-terminus of the anti-TEM1 single-chain antibody is cysteine, and is connected to the linker MAL -PEG-NH 2 through a thioether bond. The TEM1-specific fluorescent probe provided by the present invention has good specificity, high sensitivity, and no cytotoxicity. Since the anti-TEM1 single-chain antibody has a small molecular weight, it is easy to clear in serum, has low immunogenicity, and is not easy to induce Specific reaction; in addition, the TEM1-specific fluorescent probe of the present invention also has the advantages of little interference and strong penetrating power, and is suitable for clinical application. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020037752-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109678960-A |
| priorityDate | 2017-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 202.