http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106729735-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G63-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F8-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F116-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F120-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F8-34 |
| filingDate | 2017-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106729735-B |
| titleOfInvention | pH-sensitive polypeptide polymer and preparation method and application thereof |
| abstract | The invention provides a pH-sensitive polypeptide polymer and a preparation method and application thereof, wherein the pH-sensitive polypeptide polymer consists of an amphiphilic polymer and a pH-sensitive polypeptide connected to the amphiphilic polymer, the pH-sensitive polypeptide is connected to the polymer through a covalent bond to prepare the pH-sensitive polypeptide polymer, and the prepared pH-sensitive polypeptide polymer is inert in blood circulation and can exist in body fluid circulation for a long time, when reaching a tumor site, the polypeptide is protonated under the tumor microacid environment to form a α spiral structure, the therapeutic activity of the polypeptide is activated to damage a mitochondrial membrane of tumor cells and induce cell death. |
| priorityDate | 2017-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.