| abstract |
Provided herein are compositions and methods for treating autoimmune and alloimmune diseases or conditions, including rheumatoid arthritis, multiple sclerosis, Inflammatory Bowel Disease (IBD) (e.g., crohn's disease, ulcerative colitis), optic neuritis, neuromyelitis optica, sjogren's syndrome, psoriasis, systemic scleroderma, ankylosing spondylitis, autoimmune hepatitis, graft-versus-host disease (GvHD), and organ transplant rejection. The compositions useful for treating autoimmune diseases comprise a pyrrolo-pyrazole PKC inhibitor. |