http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106727425-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f6fda4df83a315a92d54398f149a8d2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01017 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 |
| filingDate | 2016-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51de4f99e3629f8a07bd505928c6244b |
| publicationDate | 2017-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106727425-A |
| titleOfInvention | A kind of preparation method of lysozyme PLGA microballoons |
| abstract | A kind of preparation method of lysozyme PLGA microballoons, belongs to field of material preparation, it is characterised in that comprise the following steps：（1）Lysozyme is dissolved in PBS liquid, interior water phase is formed；（2）Take to be dissolved in dichloromethane and form organic phase；（3）Interior water is added in organic phase, solidified microsphere is emulsified to obtain at the beginning of being carried out under condition of ice bath with ultrasonic cell disintegration instrument；（4）With deionized water centrifuge washing 3 times, lysozyme PLGA microballoons are obtained final product.With lysozyme as model drug, prepare microballoon, compare influence of the formulation factors to microballoon property in preparation process, and physicochemical property, the internal compatibility of microballoon and degradation characteristic are carried out to obtained microballoon, the microballoon monodispersity that emulsification condition is gentle, preparation process is difficult to make medicine be denatured and prepare is preferable, and preparation method process is simple of the present invention, it is easy to operate, be suitable to popularization and application. |
| priorityDate | 2016-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.