http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106727284-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-06 |
| filingDate | 2017-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106727284-B |
| titleOfInvention | Magnetic reduction enhanced drug sensitive release nanogel and preparation and storage methods thereof |
| abstract | The invention relates to a magnetic reduction enhanced drug sensitive release nanogel and a preparation and storage method thereof. The magnetic reduction enhanced drug sensitive release nanogel is prepared from superparamagnetic ferroferric oxide nanoparticles with aminated surfaces, a high molecular derivative with a side chain containing a selenium-sulfur bond and an anticancer drug according to the mass ratio of (1-2): 1: (0.2-0.5). The preparation method specifically comprises the following steps: 1) synthesizing a macromolecular derivative with a side chain containing a selenium-sulfur bond; 2) adding SPION-NH 2 The anticancer drug and the macromolecular derivative with the side chain containing the selenium-sulfur bond obtained in the step 1) are self-assembled to obtain the final product. The method for storing the nanogel is to store the nanogel in an environment at 2-4 ℃. The preparation method has mild preparation conditions, no toxic and harmful substances are introduced, the process is simple, the repeatability is good, the prepared nanogel has strong reduction sensitive release, the burst release and the drug leakage in the normal physiological environment are effectively avoided, the active magnetic targeting property is realized, and the application prospect in the field of targeted antitumor drugs is wide. |
| priorityDate | 2017-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.