| abstract |
The present invention describes anti-B7H3 antibody agents and uses related thereto. The present invention demonstrates, inter alia, the specific immunomodulatory utility of certain such antibodies. The present invention more particularly describes high affinity or otherwise applicable antibodies and antibody pharmaceuticals based thereon, including, inter alia, certain humanized and/or affinity matured versions of the 8H9 antibody. In some embodiments, provided antibody agents are useful, eg, in the treatment of cancer. In some embodiments, provided antibody agents are useful for alleviating immunosuppression, eg, mediated by B7H3 positive cells. |