http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106701840-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-743 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-22 |
| filingDate | 2016-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106701840-B |
| titleOfInvention | Biological preparation method of (1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine D-mandelate (Ⅰ) |
| abstract | The invention provides a biological preparation method of (1R,2S)-2-(3,4-difluorophenyl) cyclopropylamine D-mandelate (I). Specifically, the method of the present invention comprises the following steps: (a) in a liquid reaction system, using the compound of formula VI as a substrate, in the presence of a coenzyme, under the catalysis of carbonyl reductase, carry out an asymmetric reduction reaction, thereby forming the compound of formula V (b) the compound of formula V reacts with triethyl phosphonoacetate to obtain the compound of formula IV; (c) the compound of formula IV is subjected to aminolysis and Hoffmann degradation to form a salt with D-mandelic acid to obtain the compound of formula I. The present invention also provides a reaction system, comprising: (i) an aqueous solvent; (ii) a substrate, wherein the substrate is a compound of formula VI; (iii) a coenzyme; (iv) a carbonyl reductase; (v) a co-substrate and (vi) enzymes for coenzyme regeneration. |
| priorityDate | 2016-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 428.