| abstract |
Provided herein are compositions, methods and kits for modulating the expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits can include nucleic acid molecules (eg, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), microRNA (miRNA) or short hairpin RNA (shRNA)). The compositions and methods disclosed herein can also be used to treat conditions and disorders associated with hsp47, such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis, and renal fibrosis. |