http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106699887-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2015-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106699887-B |
| titleOfInvention | Anti-human PD-1 protein antibody and coding gene and application thereof |
| abstract | The invention discloses an anti-human PD-1 protein antibody, a coding gene and an application thereof, wherein the antibody comprises a heavy chain variable region and a light chain variable region, and the amino acid sequences of three hypervariable regions of the heavy chain variable region, namely CDRH1, CDRH2 and CDRH3, are respectively as follows: GFTFSSYAMS, AISGSGGTTYYADSVKG, AWAPFVNSIVVVTANDL, respectively; the amino acid sequences of three hypervariable regions CDRL1, CDRL2 and CDRL3 of the light chain variable region are RASQGISTWLA, AASSLQS, QQANSFPI respectively. The invention constructs a human single-chain antibody library, screens the single-chain antibody by adopting ribosome display technology, and the obtained anti-human PD-1 protein antibody can be specifically combined with human PD-1 protein, has high affinity, can be used for detecting cells expressing PD-1, can also be used as a fully human anti-human PD-1 antibody for treating human diseases, and effectively prevents and treats tumor diseases. |
| priorityDate | 2015-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 117.