http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106699871-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 |
| filingDate | 2016-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106699871-B |
| titleOfInvention | A kind of preparation method of liraglutide |
| abstract | The invention discloses a preparation method of liraglutide, which belongs to the technical field of medicine. The method of the present invention includes the following steps: 1) solid-phase synthesis of four peptide fragments of liraglutide. Wherein, peptide fragment 1 is amino acids 1-9 in the main chain sequence of liraglutide; peptide fragment 2 is amino acids 10-14 in the main chain sequence of liraglutide; peptide fragment 3 is the main amino acid of liraglutide 15-23 amino acids in the chain sequence; peptide fragment 4 is the 24-31 amino acids in the main chain sequence of liraglutide. 2) Stepwise coupling of each peptide fragment to obtain a fully protected liraglutide backbone peptide. 3) Remove the protective group of the 20th lysine, and complete the connection of the side chain to obtain a fully protected liraglutide peptide resin. 4) After cleavage, purification and freeze-drying, liraglutide is obtained. The preparation method has high production efficiency, stable process, high product purity and high yield, and is suitable for industrial production. |
| priorityDate | 2016-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 127.