| abstract |
The invention provides a programmed death receptor 1 gene inhibitor and a preparation method and application thereof. In particular to a compound for inhibiting the expression of a programmed death receptor 1 and pharmaceutically acceptable salt thereof, which has a structure shown in a formula I Wherein A is selected from C or N; r 1 Selected from H, CH 3 、(CH 2 ) 3 ‑N(CH 3 ) 2 、(CH 2 ) 2 ‑N(CH 3 ) 2 、CH 2 ‑N(CH 3 ) 2 、(CH 2 ) 3 ‑N(CH 3 )CH 2 CH 2 NHR 3 ；R 2 Selected from H, CH 3 、 R 3 Selected from H, CH 3 、 The polyamide molecule disclosed by the invention belongs to polypeptide micromolecules, can realize chemical synthesis, is favorable for large-scale production, and provides more methods for inhibiting the function of PD 1. |