| abstract |
The invention provides a programmed death receptor 1 gene inhibitor, its preparation method and application. Specifically disclosed is a compound for inhibiting the expression of programmed death receptor 1 and a pharmaceutically acceptable salt thereof, which has the structure shown in formula I, wherein A is selected from C or N; R 1 is selected from H, CH 3 , ( CH 2 ) 3 -N(CH 3 ) 2 , (CH 2 ) 2 -N(CH 3 ) 2 , CH 2 -N(CH 3 ) 2 , (CH 2 ) 3 -N(CH 3 )CH 2 CH 2 NHR 3 ; R 2 is selected from H, CH 3 , R 3 is selected from H, CH 3 , the polyamide molecule disclosed in the present invention belongs to small polypeptide molecules, can realize chemical synthesis, is conducive to large-scale production, and is the inhibitor of PD1 function Provide more methods. |