http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106636200-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2016-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106636200-B |
| titleOfInvention | A kind of the RNA interference plasmid and its application method of ZNF667 albumen |
| abstract | The invention discloses a kind of short hairpin RNA interference plasmid of ZNF667 albumen and its application methods.Short hairpin RNA (ZNF667-shRNA) interference plasmid of ZNF667 albumen is successfully constructed for the first time, is transfected into hepatoma H22 cells, and the cell strain of stable transfection ZNF667-shRNA plasmid is constructed.It was found that the proliferation of HepG2 cell, infiltration, invasion migration can be inhibited by cutting down the ZNF667 albumen in HepG2 cell.Tumor formation in nude mice confirms that the expression for cutting down ZNF667 in HepG2 cell can inhibit tumor formation from body level.Cut down the expression of the ZNF667 albumen in HepG2 cell, it may be possible to by promoting P53, inhibit Bcl-2 albumen to reach the grade malignancy for inhibiting HepG2 cell.The present invention will provide new thread and approach for the treatment of liver cancer, be of great significance. |
| priorityDate | 2016-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.