http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106632562-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 2015-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106632562-B |
| titleOfInvention | Fluorometholone refining process |
| abstract | The invention relates to the field of a refining method of a compound, in particular to a fluorometholone refining process, which is characterized by comprising the following specific process steps: (1) dissolving 100g of crude fluorometholone in one or more of 400-500mL of amide organic solvents, stirring and heating to 80-90 ℃, and keeping for 0.5 h; (2) slowly adding 1-2L of alcohol solvent, maintaining the temperature at 60-75 deg.C for 0.5 hr, cooling to 0-5 deg.C, and crystallizing at 0-5 deg.C for 12 hr; (3) filtering and drying to obtain 25-33g of white crystal fluorometholone refined product. The mass concentration of the crude fluorometholone in the step (1) is 97-98%. The invention solves the impurity problem in the refining of the fluorometholone, so that the related substances of the fluorometholone not only completely meet the requirements in British pharmacopoeia BP2008 and United states pharmacopoeia USP36, namely the purity is more than 99 percent, and the single impurity is less than 0.5 percent; moreover, the known single impurity is less than 0.15 percent, the total impurity is less than 0.1 percent, and the requirement is greatly improved compared with the requirement of pharmacopoeia. |
| priorityDate | 2015-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.