abstract |
The invention relates to a novel tridentate ligand of phosphonic acid and its application in asymmetric catalytic reaction. The novel tridentate phosphonine ligand disclosed in the present invention is the first tridentate phosphonine ligand containing a ferrocene-based planar chiral phosphine, and has been successfully applied to the efficient and high selection of simple aromatic ketones and aliphatic ketones Sexually asymmetric hydrogenation and its analogous reactions. This type of ligand has a simple synthesis route, low cost, easy large-scale synthesis, air stability, high activity and high selectivity for the asymmetric hydrogenation reaction of carbon-oxygen double bonds, and has broad industrial application prospects. |