http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106632482-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_81cdd01db91de024d36263cce0cc8e3e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65616 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 |
| filingDate | 2016-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3d425a40d24ba47488807c8aaca65da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2f123a705c8522ef17303af24e143b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fec56f925fa64e14c2b84a8cef5d4ee7 |
| publicationDate | 2017-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106632482-A |
| titleOfInvention | mPEG3 tenofovir disoproxil and preparation method thereof |
| abstract | The invention belongs to the technical field of organic compound synthesis, and relates to a pharmaceutical compound mPEG 3 -tenofovir disoproxil and a preparation method thereof. mPEG 3 ‑tenofovir disoproxil has the advantages of safety and good quality. Its preparation method is to use (R)-9-(2-hydroxypropyl) adenine as a raw material, under the action of carbonate, react with triethylene glycol monomethyl ether p-toluenesulfonate to obtain the compound shown in formula II mPEG 3- (R)-9-(2-hydroxypropyl) adenine, then react with p-toluenesulfonyloxymethyl diethyl phosphate under the action of alkali to prepare mPEG 3 shown in formula III. Fovir diethyl ester, then hydrolyzed and condensed to obtain mPEG 3 ‑tenofovir disoproxil. The preparation method of mPEG 3 -tenofovir disoproxil according to the present invention has the advantages of simple method, wide sources of raw materials, mild reaction conditions, low production cost, high overall reaction yield, and relatively stable product quality. |
| priorityDate | 2016-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.