http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106632443-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-04 |
| filingDate | 2016-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106632443-B |
| titleOfInvention | Synthesis method of 2-aminopyrimidine-5-boric acid pinacol borate |
| abstract | The invention belongs to the field of organic synthesis, and particularly relates to a synthetic method of 2-aminopyrimidine-5-boric acid pinacol borate, which comprises the following steps: taking 2-amino-5-bromopyrimidine and pinacol diborate as raw materials, wherein the mass ratio of the 2-amino-5-bromopyrimidine to the pinacol diborate is 1:0.95-2.1, and the mass ratio of the 2-amino-5-bromopyrimidine to the solvent is 1:4.0-30, continuously reacting in a proper solvent at 50-125 ℃ for 3-8 hours under the action of a specific alkali potassium acetate and a specific catalyst 1,1' -bis (diphenylphosphino) ferrocene ] palladium dichloride dichloromethane complex to generate a crude product of 2-aminopyrimidine-5-pinacol borate, and recrystallizing to obtain a pure product of the 2-aminopyrimidine-5-pinacol borate. The invention has the advantages of easily obtained raw materials, easy operation, accelerated reaction process by specific alkali and specific catalyst, shortened reaction time, high reaction yield and high purity. |
| priorityDate | 2016-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.