| abstract |
The invention discloses a preparation method of cabozantinib, which comprises diethyl malonate, 4-fluoroaniline, 4-chloro-6,7-dimethoxyquinoline, 4-aminophenol and 1,2 ‑Dibromoethane etc. are used as raw materials, and the target product cabozantinib is obtained through five-step reactions. The invention is easy to operate, environment-friendly, and has a comprehensive yield of more than 50%, which is significantly improved compared with the existing yield of 20%, greatly reduces the production cost of the existing medicine, and is suitable for industrial scale production. |