http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106631918-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-37 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-37 |
| filingDate | 2016-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106631918-B |
| titleOfInvention | The method for splitting Tamsulosin enantiomter |
| abstract | The present invention relates to the methods for splitting Tamsulosin enantiomter.Specifically, the present invention relates to a kind of method that the Tamsulosin by following formula (1) splits into itself R and S enantiomer, this method comprises the following steps：(a) solid mixture of (R) and (S) tamsulosin free base is dissolved in solvent, and the free alkali is made to be reacted with 10 sulfonic acid of camphor, to form the solution of a pair of of 10 sulfonate of diastereomeric camphor containing Tamsulosin；A kind of 10 sulfonate of diastereomeric camphor of preferential precipitation Tamsulosin from the solution of a pair of of 10 sulfonate of diastereomeric camphor for containing Tamsulosin, to form the solute for being enriched a kind of sediment of diastereomer and being enriched another diastereomer；(b) from one of the sediment rich in diastereomer and solute, tamsulosin free base is discharged, to form the tamsulosin free base of optically-active enrichment.The method of the present invention has excellent processing performance. |
| priorityDate | 2016-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.