http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106631857-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-325 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-80 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2016-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106631857-B |
| titleOfInvention | Arylamine nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-propiono -1,4- phenylenediamine and preparation method thereof |
| abstract | The invention particularly discloses the structural formulas of arylamine nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-propiono -1,4- phenylenediamine；And preparation method thereof: N, N- bis- (2- chloroethyl) -1,4- phenylenediamine are prepared first；Then by N, N- bis- (2- chloroethyl)-Isosorbide-5-Nitrae-phenylenediamine, methylene chloride and triethylamine is fitted into reactor, ice-water bath is cooling, stirring, and the mixed solution of propionyl chloride and methylene chloride is added dropwise into reactor, after being added dropwise to complete, ice-water bath is removed, is reacted at room temperature 4-14 hours, after fully reacting, washing reaction liquid, and, air-distillation dry with anhydrous cupric sulfate, to the filter cake after distillation purified to get.Under the premise of having enhancing mustargen therapeutic index and the toxic side effect of mustargen can be effectively reduced, while having both the curative effect of sterilization, anti-inflammatory in arylamine nitrogen mustard derivatives of the invention, with reach reduce chemotherapy of patients after because of caused by immunity degradation complication risk. |
| priorityDate | 2016-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.