| abstract |
The invention provides a method for improving the structure of intestinal flora, and its application in preparing medicines, nutritional products, health products, food and beverages for regulating intestinal flora. High-throughput sequencing technology and multivariate statistical methods were used to identify gut bacterial groups closely related to host metabolism. Taking berberine as an example, a new method for improving the structure of intestinal flora has been established, including selectively increasing some bacteria, such as short-chain fatty acid producing bacteria, etc., and at the same time inhibiting some bacteria, such as bacteria that can produce endotoxin, etc. , thereby preventing or treating disorders of the metabolic or immune system including increased levels of systemic inflammation, obesity, insulin resistance, etc. induced by improper diet. The invention also provides a method for screening drugs, compounds and foods with similar effects, and a composition for improving the structure of intestinal flora. The invention can be used for the development of medicines, nutritional products, health products, food, beverages, etc. targeting intestinal flora. |