http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106619495-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1079d1e449c6a787a6e12b23d705256a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12 |
| filingDate | 2016-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6384bfab9c0d3d9ed30f5a359fd830a0 |
| publicationDate | 2017-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106619495-A |
| titleOfInvention | Preparation method of nalmefene hydrochloride injection and nalmefene hydrochloride injection prepared with method |
| abstract | The invention discloses a preparation method of a nalmefene hydrochloride injection. When the nalmefene hydrochloride injection is prepared with a conventional method, a certain quantity of citric acid or citrate auxiliary material is added to the preparation, and 5-15 g of the citric acid or citrate auxiliary material is added in each liter of the injection. During preparation, the prescription quantity of the auxiliary material is dissolved in water for injection firstly, then activated carbon is added with stirring for adsorption, and filtration is performed for impurity removal; the prescription amount of nalmefene hydrochloride is added under the nitrogen protection, after full dissolution, the solution is metered to the designated volume with water, the pH value is adjusted to 3.5-4.5, and finally, the solution is filtered by a filter, sub-packaged, filled with nitrogen, sealed and sterilized. With the adoption of the method, the expiry date of the nalmefene hydrochloride injection can be obviously prolonged, the stability is good due to adoption of a specific citric acid pH value stabilizer, the sample appearance properties, pH value, effective ingredient content, related substances and the like are relatively stable, and the medication safety is guaranteed. |
| priorityDate | 2016-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.