abstract |
The present invention relates to novel benzodiazepines with antiproliferative activity Derivatives, and more particularly, novel benzodiazepines of formula (I)-(VI) compound. The present invention also provides benzodiazepines linked to cell-binding agents Compound Conjugates. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating proliferative disorders in a mammal using the compounds or conjugates of the invention. |