abstract |
The invention relates to pyridyl-substituted 6-oxaspiro[4.5]decane derivatives, a preparation method thereof and application in medicine. Specifically, the present invention relates to pyridyl-substituted 6-oxaspiro[4.5]decane derivatives as shown in formula (I), a preparation method and a pharmaceutical composition containing the compound, and it can be used as MOR The use of receptor agonists, the compound and the pharmaceutical composition containing the compound can be used to treat pain and pain-related disorders, wherein R 1 in the general formula (I) is the same as defined in the description. |