| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-22 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 |
| filingDate |
2016-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8d5cf4cd4c6f428fab67f552f4c53c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8becf2ba8f3f4206e5bc946bade94eaf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0759d4d3729c1919f3b72c5095ecf69e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b195d29c579c05f032c276bf0ffaadd4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe3207637db5e640606f7b370974b20c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab5189745f98ca0b2440cd92f83babfc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4ed6f3b3aff083c2da2f7407fd950f1 |
| publicationDate |
2017-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-106588826-A |
| titleOfInvention |
Aspirin-paclitaxel anticancer drug conjugate, synthesis method and application thereof |
| abstract |
The invention discloses an aspirin-paclitaxel anticancer drug conjugate, the structure of which is shown in the formula (1): in the formula (1): A is derived from an anticancer drug capable of esterifying with the carboxyl group of aspirin, and the anticancer drug The cancer drugs are paclitaxel drugs. The invention discloses a preparation method of an aspirin anticancer drug conjugate, which comprises: carrying out acylation reaction of aspirin or an aspirin precursor compound and an anticancer drug in an organic solvent to prepare the aspirin anticancer drug conjugate thing. The invention also discloses the effect of an aspirin-anticancer drug conjugate on inhibiting tumor cell proliferation. The present invention couples aspirin with camptothecin drugs or paclitaxel drugs, combines the synergistic effect of aspirin and anticancer drugs, and further increases the inhibitory effect on tumor cells. Compared with simple antitumor drugs, the present invention The aspirin drug conjugate obtained by the invention has achieved good synergistic performance. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113603727-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113603727-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111662251-A |
| priorityDate |
2016-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |