http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106581676-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-00 |
| filingDate | 2017-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106581676-B |
| titleOfInvention | Cancer marker, pharmaceutical composition for treating cancer and application |
| abstract | The invention belongs to the technical field of microRNA for cancer diagnosis and treatment, and particularly relates to a cancer marker, a medicine component for treating cancer and application thereof, wherein the cancer marker contains miR-4767 antisense nucleotide miR-4767 ASO, or is modified or contains mismatched bases. The pharmaceutical composition for treating cancer as a medicament for down-regulating the expression level of target genes GRAMD4, BRI3BP, TNFSF15, MOB1A, STK11, PHLDA3, BBC3 and MAD2L 2. The invention discovers that the antisense nucleic acid of miR-4767 can specifically kill various cancer cells by screening a nucleic acid drug library, and also proves that the modified antisense nucleic acid (comprising thio modification, LNA modification and the like) of miR-4767 can better kill cancer cells, and the antisense nucleic acid of miR-4767 containing mismatched bases can also partially inhibit the function of miR-4767. Therefore, miR-4767 is believed to be a new good target for treating cancers, and the inhibitor of miR-4767 (comprising antisense nucleic acid and interfering RNA thereof) can treat and/or prevent cancers such as liver cancer and lung cancer possibly, thereby bringing huge social and economic benefits. |
| priorityDate | 2017-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 84.