http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106581645-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5123 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-26 |
| filingDate | 2016-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106581645-B |
| titleOfInvention | Vitamin B loaded with medicine12Derivative self-assembled nano-particles, preparation method and application |
| abstract | The invention discloses a vitamin B loaded with medicine 12 Derivative self-assembly nanometer particles, a preparation method and application. The invention respectively dissolves the drug and the phenylalanine dipeptide in hexafluoroisopropanol to obtain a solution A and a solution B; mixing vitamin B as shown in formula I 12 Dissolving the derivative in hexafluoroisopropanol to obtain a solution C; uniformly mixing an organic solvent or a solution thereof with the solution A to obtain a solution D; uniformly mixing the solution B and the solution C, adding the mixture into the solution D, and uniformly mixing to obtain a solution E; mixing the solution E with water, adding PEG200, and mixing to obtain solution F; freeze drying, adding water, and resuspending to obtain vitamin B loaded with medicine 12 The derivatives self-assemble nanoparticles. The nanometer particle contains vitamin B 12 Therefore, a plurality of drug molecules can pass through intestinal mucosa to enter portal circulation in an active transportation mode, and the treatment effect of the administration dosage is ensured. |
| priorityDate | 2016-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 140.