| abstract |
Disclosed herein are chimeric flaviviruses comprising non-coding regions, non-structural proteins, and at least a portion of C protein from West Nile Virus (WNV), and prM and E proteins from dengue virus (DENV). The DENV may be DEN1 serotype, DEN2 serotype, DEN3 serotype, or DEN4 serotype. Also disclosed herein are compositions and methods for eliciting an immune response (such as an immune response against one or more DENV serotypes) in a subject. In particular embodiments, the compositions include one or more inactivated viruses including a WN/DENV chimeric nucleic acid (e.g., a tetravalent inactivated vaccine including a WN/DEN1 chimera, a WN/DEN2 chimera, a WN/DEN3 chimera, and a WN/DEN4 chimera). The composition can be administered to a subject to elicit an immune response. |