| abstract |
The application provides a compound of formula (J) or a pharmaceutically acceptable salt, isomer, tautomer or mixture thereof, wherein n, m, R 1 , R 2 , R 3 , R 4 and R 5 are described in In this application. The compound is an inhibitor of phosphatidylinositol 3-kinase (PI3K) activity, and can be used to treat diseases mediated by one or more subtypes of PI3K. The application also provides pharmaceutical compositions comprising compounds of formula (I) or pharmaceutically acceptable salts, isomers, tautomers or mixtures thereof, and the use of these compounds and compositions to treat A method for subtype-mediated disorders. |