http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106565750-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-06 |
| filingDate | 2016-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106565750-B |
| titleOfInvention | A kind of synthetic method of dextrocefamandolic acid |
| abstract | The invention discloses a method for synthesizing D-cefamandolic acid. The method is to use the boron trifluoride complex of the mono-organic solvent as a catalyst to synthesize 7-ACA and methylmercaptotetrazolium in a mono-organic solvent. Condensation to generate 7‑ATCA; then in another monobasic organic solvent, under the action of an organic base, 7‑ATCA is reacted with S‑(‑)‑formylmandelic acid chloride to generate dextrocefamandolic acid, and then undergoes hydrolysis , extract and separate phases, leave the organic phase, and add organic acid sodium salt and another organic solvent that is insoluble with dextrocefamandoxil sodium, crystallize to obtain dextrocefamandole sodium, and finally dextrocefamandoxil sodium The sodium ester is dissolved in water, a water-insoluble organic solvent and an organic or inorganic acid are added, the organic phase is left after extraction and phase separation, and the organic phase is rotary evaporated under reduced pressure to obtain dexcefamandolic acid. The method of the invention is simple, the conditions are mild, the raw materials are easy to obtain, and the purity of the finally obtained product is above 99%. |
| priorityDate | 2016-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.