| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56d9856858f491640008656f9086efaa |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2016-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eda93b958d6839cb9402692ef13a3d6d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bac85811828389f3b7792ef34d304cbe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f736eaebaf29a4c010ff8a90d5e33bd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cb476b1bbe179e573f25ee1614ea429
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0332f41dcd42571bd39f8083ca3fb2a8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc7259f0a67930ce0a25cf35d9e3cbca |
| publicationDate |
2017-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-106565589-A |
| titleOfInvention |
A kind of preparation method and application of hydrazide indole drugs |
| abstract |
A preparation method and application of hydrazide indole drugs. The invention discloses a class of 2-hydrazide substituted indole compounds and their preparation method and application. The new 2-hydrazide substituted indole compound exhibits a very high activity of inhibiting tumor cell growth, especially for the growth of vascular epidermis The growth of human rectal cancer cells and colon cancer cells with high expression of factor receptor 2 subtype has a significant inhibitory effect, and its IC50 value can reach about 10μM, and it has good anti-vascular effects in the CAM (chick embryo allantoic membrane) model Compound 21 has better anti-VEGF-stimulated HUVEC cell proliferation ability and anti-VEGF-stimulated HUVEC proliferation specificity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114380732-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110622982-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113101287-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110128343-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112939868-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114989131-A |
| priorityDate |
2016-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |