http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106565510-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-46 |
| filingDate | 2015-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106565510-B |
| titleOfInvention | The preparation method of trans 4- Amino-cyclohexvls acetic ester derivative |
| abstract | The present invention provides the preparation method of trans 4 aminocyclohexyl acetic ester derivative, this method comprises the following steps： Wherein R is methyl or ethyl.Using 4 aminocyclohexanone II as raw material prepare compound III, compound III hydro-reductions obtain compound I crude products, and acid adding adds alkali prepare compound I into salt.The present invention uses 4 aminocyclohexanones without amido protecting to carry out Wittig reaction witting for raw material, then obtains the trans crude product of the present invention by catalytic hydrogenation, which can be trans through crystallizing to obtain purer trans product into salt：Cis ratio is 95 99.9:5‑0.1.Product compound purity of the present invention is high, is advantageously used for preparing Cariliprazine, the present invention is easy to operate, and raw material is easy to get, and is suitable for industrialized production, there is larger application value. |
| priorityDate | 2015-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 116.