http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106560473-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 |
| filingDate | 2016-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106560473-B |
| titleOfInvention | A kind of improved Bardoxolone lactone derivatives synthesis technique |
| abstract | The invention discloses a kind of improved Bardoxolone lactone derivatives synthesis technique, using oleanolic acid as initiation material, it is prepared in accordance with the following steps：Step a, oleanolic acid lactonize to obtain the compound shown in chemical formula II, introduce lactonic ring；Step b, the compound oxidation shown in chemical formula II obtain the compound shown in chemical formula III, introduce α, beta unsaturated ketone group；Step c, the compound iodate shown in chemical formula III obtain the compound shown in chemical formula IV；Step d, the compound itrile group shown in chemical formula IV obtain the Bardoxolone lactone derivatives shown in chemical formula I.Synthesis technique step of the present invention is few, significantly reduces human cost；Raw material availability is high, and excessive intermediate impurities and residual solvent will not be introduced in end-product, is suitable for industrialized production, and yield is high, purity is high, is easy to quality control. |
| priorityDate | 2016-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.