http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106554361-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-34 |
| filingDate | 2016-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106554361-B |
| titleOfInvention | A kind of preparation method of CEFUROXIME AXETIL oral preparation |
| abstract | The invention discloses a kind of preparation methods of CEFUROXIME AXETIL oral preparation,Belong to pharmaceutical manufacturing field,Including synthesizing CEFUROXIME AXETIL with bromoacetate solution reaction with cefuroxime acid,Then by extraction,Decoloration,Concentration,Crystallization,The process of oral preparation is made in spray drying,Present invention improves over the reaction process of synthesis CEFUROXIME AXETIL,By cefuroxime acid,Bromoacetate and potassium carbonate are added in potassium carbonate dimethylacetylamide suspension within a certain period of time simultaneously,And invention also improves the crystallization process of CEFUROXIME AXETIL,By the suspension of CEFUROXIME AXETIL isopropyl ether or CEFUROXIME AXETIL petroleum ether and CEFUROXIME AXETIL reaction solution,It is added in ethyl acetate solution simultaneously within a certain period of time and carries out separation organic phase,This improves at two to play keeps the stability of concentration of substrate and pH value in reaction well,Greatly reduce side reaction,Play the role of to raising product quality prodigious,Make final product purity higher. |
| priorityDate | 2016-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 101.