http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106551930-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-02 |
| filingDate | 2015-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106551930-B |
| titleOfInvention | Application of the tetrahydropalmatine in anti-toxicity of cisplatin medicine is prepared |
| abstract | The present invention provides application of the tetrahydropalmatine in anti-toxicity of cisplatin medicine is prepared.The toxicity includes Toxicity of Kidney, ototoxicity and neurotoxicity.Research shows that tetrahydropalmatine is inhibited with MATE1 to OCT2, cytotoxicity caused by energy antagonism cis-platinum, and is preferably verified on the renal cells model of original cuiture.And using () THP as representative, research finds that tetrahydropalmatine has good protective effect to cis-platinum induced mice injury of kidney.Therefore, tetrahydropalmatine shares with cis-platinum, is likely to reduced cis-platinum and is accumulated in kidney, cells,cochlear and DRGs, so as to reach prevention or reduce the expected results of toxicity of cisplatin.The present invention has expanded the new application of tetrahydropalmatine；Due to the high expression OCT2 of kidney, cochlear hair cell and DRGs, and often lack OCT2 expression on tumour cell, cis-platinum has certain passive permeability, therefore, tetrahydropalmatine shares with cis-platinum, while decrease cis-platinum institute is causing toxicity, can't reduce the antitumous effect of cis-platinum. |
| priorityDate | 2015-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.