http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106543060-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C403-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-32 |
| filingDate | 2016-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106543060-B |
| titleOfInvention | A kind of difficult to understand this replaces the preparation method of Buddhist nun's mesylate |
| abstract | The preparation method that this replaces Buddhist nun's mesylate the invention discloses a kind of Austria.- 4 (3H) -one of 2- chlorine pyrimidine and the fluoro- 2- methoxyl groups -5- nitroanilines of 4- are carried out substitution reaction by this method；Obtained 2- (the fluoro- 2- methoxyl groups -5- nitrobenzenes amino of 4-) (3H) -one of pyrimidine -4 and N, N, N'- trimethyl ethylenediamine are subjected to substitution reaction；Obtained 2- (4- (N- (2- (dimethylamino) ethyl)-N- methylaminos) -2- methoxyl group -5- nitrobenzenes amino) pyrimidine -4 (3H) -one is subjected to nitro-reduction reaction；Obtained 2- (4- (N- (2- (dimethylamino) ethyl)-N- methylaminos) -2- methoxyl group -5- amino phenyl aminos) pyrimidine -4 (3H) -one is subjected to chlorination；Obtained 2- (4- (N- (2- (dimethylamino) ethyl)-N- methylaminos) -2- methoxyl group -5- amino phenyl aminos) -4- chlorine pyrimidines and 1- Methyl-1H-indoles are subjected to condensation reaction；Obtained 2- (4- (N- (2- (dimethylamino) ethyl)-N- methylaminos) -2- methoxyl group -5- amino phenyl aminos) -4- (1- Methyl-1H-indole -3- bases) pyrimidines and acryloyl chloride are subjected to amidation process, salt-forming reaction is finally carried out, difficult to understand this is obtained and replaces Buddhist nun's mesylate.The process route of this method is rationally succinct, and operation simplifies, and cost is relatively low, is a kind of environmentally protective method, is suitable for industrialized production. |
| priorityDate | 2016-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 154.