http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106520708-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-768 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-768 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 |
| filingDate | 2016-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106520708-B |
| titleOfInvention | A kind of application of the oncolytic adenovirus of TGF-β targeting in kidney treatment |
| abstract | The present invention relates to biotechnologys and field of gene, in particular, provide a kind of oncolytic adenovirus and preparation method thereof of TGF-β targeting, and its verifying for replicating, killing and expressing in kidney cancer cell, and the application in kidney treatment.The oncolytic adenovirus expresses the fusion protein sTGF β RIIFc of TGF beta receptor soluble fragments and human IgG1 Fc by the duplication of telomerase promoter TERTp regulation virus.The oncolytic virus can in kidney cancer cell massive duplication and killing tumor cell, while express express target protein sTGF β RIIFc；Destination protein sTGF β RIIFc can target TGF-β signal, and the metastases for blocking TGF-β to mediate inhibit immunosupress caused by TGF-β, to achieve the purpose that treat tumour and its transfer. |
| priorityDate | 2016-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 126.