http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106518879-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_08f13af9eed1607b6583a1306d9a1294 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2016-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86b81a8beefce4e02b33eb7d6ee464f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_238ffb461d8d5505f50119ce78298626 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdfe30f1f5de4a1fc213060b07d85170 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_137ff5f6c178b669a13d42ff092db53a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34ecfc4762375a1f0e5d0b4f34e6c40c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5882c22edc8745a2f71ea22debcc27bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4a967e94249527a67193589a442c009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b9493b48ca8973db1fa8c2be4a4ca28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4f07b1d58908898701bd1e1fa74d024 |
| publicationDate | 2017-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106518879-A |
| titleOfInvention | A class of 2,3-lactam ring fused quinazoline-4(3H)-one derivatives, preparation methods and applications thereof |
| abstract | The invention discloses a class of 2,3-lactam ring fused quinazoline-4(3H)-one derivatives, a preparation method and applications thereof. According to the present invention, a series of novel-structure simplified tricyclic fused quinazoline derivatives are designed and synthesized by using the fused quinazoline ring contained in a natural product luotonin A as a template, and an anti-liver-cancer-cell activity testing experiment is performed on the derivatives, such that a certain research direction is provided for the structural transformation of the luotonin and the camptothecin, and the novel guide structure is provided for the further discovery of the antitumor drugs. According to the present invention, the results of the multiple tests verify that the method relates to the continuous 4-5 step traditional chemical reaction (intermolecular cyclization, alkylation, amination, intramolecular cyclization and substitution), it is proved that the yield of the final product is easily improved by setting the reaction sequence from a plurality of the fields, the whole synthesis route for the synthesis of the compounds is firstly and publicly reported, and the reference method can be provided for the synthesis of a large number of the derivatives and the structural transformation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113662944-A |
| priorityDate | 2016-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 160.