| abstract |
The present invention relates to pyrazine compounds useful as ATR protein kinase inhibitors. The present invention also relates to pharmaceutically acceptable compositions comprising the compounds of the present invention; methods of using the compounds of the present invention to treat various diseases, disorders and conditions; methods of preparing the compounds of the present invention; intermediates for the preparation of the compounds of the present invention; and in vitro Methods of using the compounds in applications such as the study of kinases in biological and pathological phenomena; the study of such kinase-mediated intracellular signal transduction pathways; and the comparative evaluation of new kinase inhibitors . The compounds of the present invention have formula I, wherein the variables are as defined herein. |