| abstract |
The present invention provides a kind of cyclohexane derivant or its stereoisomer or salt and its preparation and application.The structure of the cyclohexane derivant is as shown in following formula I B: Pharmacological tests show: cyclohexane derivant of the invention is to D 3 Receptor, serotonin have compared with strong affinity, and to D 2 Receptor affinity is then weaker, shows to D 3 /D 2 Receptor it is highly selective, reached unexpected effect, be the therapeutic agent of a kind of novel anti-neuropsychiatric disease, there is preferable potential applicability in clinical practice and social benefit.Preparation method is simple by the present invention, is suitable for industrialized production, there is biggish application value. |