http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106518832-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6ed83b9d5c28c6c356d1d08d58501e7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-78 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-78 |
| filingDate | 2017-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c27207e6faae0626c5b266039e591090 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ebe190596e705321a7dee76cfc33fec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ee60bc166359e7c357c5537d623d0bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99023c7870c6d0024679d2e8db331627 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42a23495c12a46a9c999b88f6dde645d |
| publicationDate | 2017-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106518832-A |
| titleOfInvention | Preparation method of velpatasvir intermediate 9-bromine-3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo [c,g] chromene-8(9h)-ketone |
| abstract | The invention relates to a preparation method of a velpatasvir intermediate 9-bromine-3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo [c,g] chromene-8(9h)-ketone. The compound is the key intermediate of velpatasvir. The preparation method is characterized in that a compound I is used as the raw material to react with 2-ethyleneoxy ethanol to obtain a compound II, the compound II is hydrolyzed under an acid condition to generate a compound III, and the compound III is brominated by tribromo pyridine to obtain the 9-bromine-3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo [c,g] chromene-8(9h)-ketone (intermediate A). The preparation method has the advantages that an original synthesizing route is shortened, and the method is stable in product quality, high in yield, simple in post-treatment and suitable for industrial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109020944-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109020944-B |
| priorityDate | 2017-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.