http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106518825-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-16 |
| filingDate | 2015-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106518825-B |
| titleOfInvention | A kind of chemo-selective monomethylation method of cumarin catechol |
| abstract | A kind of chemo-selective monomethylation method that the present invention provides cumarin catechol belongs to natural drug synthesis field, this method is by pyrocatechol coumarin compound, it is added under the organic reaction system of appropriate base catalyst, highly selective methylation reaction occurs with methylating reagent, and then obtain monomethylation product, the alkali and pyrocatechol coumarin compound and molar ratio are as follows: 1.0~5.0:1；The methylating reagent and pyrocatechol coumarin compound and molar ratio are as follows: 1.0~2.0:1, the temperature of reaction system are -20~10 DEG C；Reaction time is 0.5~3 hour.This method has the characteristics that easy to operate, mild condition, selectivity is good, yield is high, the monomethylation product preparation for the cumarin pyrocatechol that can be used for having different type substituent group. |
| priorityDate | 2015-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.