http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106518760-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_656facf073afb777f5258e2ab54d2338 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-44 |
| filingDate | 2016-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ab793b00a4ce0676697479529f20ba1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e62d3ed204525816c280fad1d71038a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82e42dc68002fd5e263d9feb921ed0a0 |
| publicationDate | 2017-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106518760-A |
| titleOfInvention | A kind of 4-aminoquinoline compound and preparation method thereof |
| abstract | The invention provides a 4-aminoquinoline compound and a preparation method thereof, belonging to the technical field of organic synthesis chemistry. The structural formula of the compound is shown in formula I or formula II. The present invention also provides a preparation method of 4-aminoquinoline compound, which uses simple and easy-to-obtain α-carbonyl dithioketene and amine as raw materials. Under acidic conditions, the imino-N,S-ketal was synthesized; or the imino-N,S-ketal was prepared by the three-component reaction of enaminone, isothiocyanate and halogenated hydrocarbon under basic conditions. S-ketal, two different functional groups are introduced into the reaction system, and then the imino-N,S-ketal is catalyzed by a cheap copper salt to synthesize a variety of 4-aminoquinolines compound. The invention has the advantages of cheap and easy-to-obtain raw materials, simple method, mild reaction conditions, wide application range of reaction, flexibility and changeability, and avoiding the use of noble metal catalysis. |
| priorityDate | 2016-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.