http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106518718-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c179f66194ad985f6d63737bd6bb4cea |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C243-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C241-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C55-07 |
| filingDate | 2015-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18844da9b262380a2e8b3f8d1bfeb9ee |
| publicationDate | 2017-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106518718-A |
| titleOfInvention | Preparation method of 4-fluorophenylhydrazine oxalate |
| abstract | The invention relates to a preparation method of 4-fluorophenylhydrazine oxalate. The preparation method comprises the steps of diazotization, reduction, purification and salification. In the steps of diazotization and reduction, reaction liquid is kept at strong acidity with concentrated hydrochloric acid to guarantee successful and complete reaction; in the reduction step, zinc powder-concentrated hydrochloric acid is used as a reducing agent and replaces sodium thiosulfate, sodium hydrogen sulfite, stannous chloride-hydrochloric acid and the like, so that the reducing property is high, the yield is high, and the reaction time is shortened; impurities, such as zinc hydroxide, which are generated after reaction are convenient to remove, so that the number of product impurities is small, and the purity is high; in the salification step, leaching is carried out with acetone, so that the purity of a product is improved, and the appearance of the product is guaranteed. The preparation method is stable and reliable in process, easy to operate and high in product purity (the content measured based on high performance liquid chromatography is greater than or equal to 99.2 percent); the yield is greater than or equal to 42 percent, so that the requirement of the market for the 4-fluorophenylhydrazine oxalate can be completely met. |
| priorityDate | 2015-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.