http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106511283-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 |
| filingDate | 2016-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106511283-B |
| titleOfInvention | A kind of lyophilized technique of clindamycin phosphate for injection |
| abstract | A kind of lyophilized technique of clindamycin phosphate for injection, it is characterised in that: successively include the following steps: (1) pre-freeze；(2) lyophilizations, using six segmentation ladder-elevating temperatures: refrigerant is heated up to -5 DEG C ± 1 DEG C by a., keeps the temperature 0.5 ~ 1.5 h；When vacuum degree reaches 15Pa ± 3Pa, autopulse permeation stops permeation when vacuum degree reaches 20Pa ± 5Pa；B. refrigerant is heated up to 5 DEG C ± 1 DEG C, keeps the temperature 1 ~ 1.5 h, pulsation permeation to 20Pa ± 5Pa；C. refrigerant is heated up to 10 DEG C ± 1 DEG C, keeps the temperature 2 ~ 2.5 h, pulsation permeation to 20Pa ± 5Pa；D. refrigerant is heated up to 15 DEG C ± 1 DEG C, keeps the temperature 2 ~ 2.5 h, pulsation permeation to 20Pa ± 5Pa；E. refrigerant is heated up to 20 DEG C ± 1 DEG C, keeps the temperature 2 ~ 2.5h, pulsation permeation to 20Pa ± 5Pa；F. refrigerant is heated up to 25 DEG C ± 1 DEG C, keeps the temperature 1.5 ~ 2 h, pulsation permeation to 33Pa ± 3Pa；(3) lyophilization again.Lyophilized technique of the present invention can either ensure that finished product moisture content and the limit of impurities meet the requirement of " national drug standards ", additionally it is possible to shorten the time of entire freeze-drying process. |
| priorityDate | 2016-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.