| abstract |
The invention discloses EGF is used for the purposes in the medicine for diagnosing or treating Implantation matastasis cancer in screening, belong to medical domain.The invention demonstrates that being closely connected between TAM (TAM) correlation orbicule and oophoroma clinical pathology, the epithelial ovarian cancer model that sets up in mouse shows TAM in the formation of oophoroma Implantation matastasis early promotion spheroid and the growth of tumour, after EGFR on the EGF activation tumour cells of TAM secretions, which raises periphery tumour cell VEGFs VEGFRs pathway signal transductions in turn and promotes tumor cell proliferation and differentiation, and EGF can raise expression of 2 integral proteins of α M β in TAM, ICAM 1 on tumour cell, tumour cell TAM is promoted to be associated.In mouse remove TAM, drug block EGFR or with antibody in and ICAM 1 after will hinder spheroid formed and ovarian cancer progress, the present invention discloses a kind of new mechanism that TAM mediation spheroids are formed, and the cancer for oophoroma and other far-end transfers is provided a kind of new targeted therapy by this. |