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filingDate 2016-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2019-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2019-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-106497931-B
titleOfInvention A kind of ssDNA aptamers for Her3ECD and its application in diagnoses and treatment HER3 related disease
abstract Fas lignand system evolution technology (the systematic evolution of ligands by exponential enrichment that the invention discloses a kind of by index concentration, what SELEX) screening obtained is directed to HER3 extracellular region protein (extracellular domain, ECD) high-affinity, highly selective DNA aptamers.The present invention further proves that the aptamers either still all have certain specificity and compatibility to the breast cancer cell of high expression Her3ECD albumen to free Her3ECD by ELISA, cell streaming, laser co-focusing experiment, and the diagnoses and treatment for the highly expressed related disease of HER3 provides new thinking.
priorityDate 2016-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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