http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106478757-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 |
| filingDate | 2016-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106478757-B |
| titleOfInvention | 3 α of one kind, 7-6 α of alpha-dihydroxy-ethyl cholanic acid preparation method |
| abstract | The invention belongs to technical field of medicine synthesis, disclose 3 α of one kind, 7-6 α of alpha-dihydroxy-ethyl cholanic acid preparation method.Using 3 Alpha-hydroxy -7- carbonyl cholanic acids as raw material, after esterification under alkalinity and cryogenic conditions, react to obtain 3 α, 7- bis- (trimethylsiloxy group) -6- alkene-cholanic acid methyl esters as catalyst with halosilanes using estersil；Then 3 Alpha-hydroxy -6- ethylidene -7- carbonyl cholanic acid methyl esters are obtained with mountain aldol reaction under the conditions of low temperature and boron trifluoride acetonitrile；Again using palladium carbon as catalyst, catalytic hydrogenation and deprotection reaction are carried out in alkaline alcohol/aqueous solution, 3-6 α of Alpha-hydroxy-ethyl-7- carbonyl cholanic acid is obtained after acidification；Finally target product is obtained using sodium borohydride reduction.Method synthesis technology of the invention is simple, mild condition, and yield is high, is suitable for industrialization. |
| priorityDate | 2016-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.